Endocrine Abstracts

Background: Generalized glucocorticoid resistance is a rare condition characterized by partial, end-organ insensitivity to glucocorticoids, compensatory elevations in ACTH and cortisol secretion, and increased production of adrenal steroids with androgenic and/or mineralocorticoid activity. We identified a new case of glucocorticoid resistance caused by a novel, heterozygous point mutation at nucleotide position 2209 (T → C) of the hGRα gene, resulting in phenylalan...

Although the primary aldosteronism (PA) is the most common endocrinological hypertension accounted for approximately 10% of all hypertension population, the subtype classification criteria of adrenal venous samplings (AVS) have been still controversial. Thus, we demonstrated the several different criteria to diagnose the unilateral hyper-aldosteronism (UHA) suspected as adenomas in our series of patients with PA.This study is included 213 AVS performed P...

Introduction: It is known that many patients with adrenal incidentaloma display altered glucose tolerance. However, to our knowledge, we have no reports of the frequency of adrenal tumor in Japanese type 2 diabetic patients. We investigated the frequency of adrenal tumor in these patients.Subjects: We evaluated the presence of adrenal tumor in 245 Japanese type 2 diabetic patients (mean age 60.8±13.4 years). The patients who were diagnosed malignant...

Objective: Osteoporosis and osteopenia (OS/OP) are frequent in patients with cortisol-producing adrenal adenomas (CPA) associated with severity of cortisol excess (CE). However, the relationship between OS/OP and CE severity considering sex differences is unknown.Patients and Methods: This was a retrospective cross-sectional observational study conducted as a part of the Advancing Care and Pathogenesis of Intractable Adrenal Disease in Japan (ACPA-J) stu...